Sullivan and Natasha's past is revealed. Ben and Bailey have a discussion with Pru's grandparents. The crew responds to a fire at a candy factory.

Emily agrees to help Bill test her for the virus, but soon experiences serious side effects. Sacha, who has secretly followed the group to stay close to Emily, tries to remove her from the group. For their part, Catherine, Sophia and Nathan set out again in search of Bill Ward.

Catherine, Sophia, Zoe and the other survivors, finally reunited, prepare for the ultimate attack. But it is Bill who is the only one to hold the destiny of humanity in his hands, provided he is helped by Isla.

M.O.D.O.K brings Melissa and Lou along to a remote GRUMBL leadership conference. After learning that he's not the guest of honor, M.O.D.O.K. enlists Melissa's help in manipulating the executives into respecting him. His schemes accidentally lead to him opening up a portal that brings the dangerously hedonistic alien species, the Ciegrimites, to the conference. While the aliens are initially the life of the party, executives begin to drop dead from partying too hard, leading M.O.D.O.K. and Melissa to wipe out the Ciegrimites and save the conference.

After getting kicked out of the A-List villains' Soho Lair, M.O.D.O.K. decides to slum it at The Bar With No Name. There, he forms a crew of street-level baddies, intent on using them for a heist that will get him back into the Soho Lair. However, after a wild night of bonding and backstory sharing, they form a real camaraderie. Meanwhile, Jodie goes looking for M.O.D.O.K. at AIM and bonds with Monica while Lou meets Monica's daughter, Carmilla. College-aged M.O.D.O.K. has returned from the time stream and kidnaps the Super Adaptoid.

With Adina's plan in motion, the world's last hope is for Bill to make one more journey, risking his own life in search of Catherine's help.

After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own; confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.

The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations; Meredith spends time with Amelia.

Carlos and Gabrielle decide to adopt, but the process comes to be a lot more difficult than either had expected. Susan finally has her surgery as she finally has medical insurance. Meanwhile, a showdown between Bree and her son Andrew lead to a full out war between mother and son. Also, a dying Noah Taylor learns more about Paul Young and his biological grandson Zach. Lastly, Tom is having more difficulty at the job when having to take orders from his boss and wife Lynette.

Susan invites Dr. Ron to meet Karl after he finds out about their arranged marriage. Lynette is surprised that a woman at work is still breastfeeding her child of five. Gabrielle becomes very picky when choosing a birth mother, and a beautiful baby. Bree has to deal with a fresh accusation from Andrew, that of repressed memories.

Lane Hunter's victims and their families become outraged when she is released from prison. Bell, although responsible for posting Lane's bail and getting her released, continues to be tortured by her manipulation.

After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own; confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.

The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations; Meredith spends time with Amelia.

Carlos and Gabrielle decide to adopt, but the process comes to be a lot more difficult than either had expected. Susan finally has her surgery as she finally has medical insurance. Meanwhile, a showdown between Bree and her son Andrew lead to a full out war between mother and son. Also, a dying Noah Taylor learns more about Paul Young and his biological grandson Zach. Lastly, Tom is having more difficulty at the job when having to take orders from his boss and wife Lynette.

Susan invites Dr. Ron to meet Karl after he finds out about their arranged marriage. Lynette is surprised that a woman at work is still breastfeeding her child of five. Gabrielle becomes very picky when choosing a birth mother, and a beautiful baby. Bree has to deal with a fresh accusation from Andrew, that of repressed memories.

When a female astronaut is found dead, Rosie and Villa launch into an investigation of America’s space program. Rosie navigates new dynamics regarding his latest health issue, and Villa’s long-lost brother returns to Miami.

When a medical device fails on a former Chastain employee, an investigation is opened up, which pits Dr. AJ Austin against Quovadis. As Mina and Bell work to get to the bottom of what went wrong, Devon distracts himself with another patient who's experiencing mysterious stomach pains. Meanwhile, Nic forms a bond with her new partner at the clinic and Conrad's relationship with the Barnett family continues to grow.

A high-risk lung transplant pushes the surgical team to their limits; Bailey juggles a trauma patient whose treatment hangs in the balance.

The interns juggle a bizarre trauma; a complex breast reconstruction forces Meredith into a tense partnership.

Carlos and Gaby learn the truth about their baby. An ex-stripper gives birth to her child, and Gabrielle holds her for the first time. Also, Paul Young comes to face his demons head on with Wisteria Lane. Lastly, Lynette is forced to give a court deposition about Bree's drinking and alcoholism.

Lynette is called in to her kids' school as Parker has gone from being obsessed with Dinosaurs to being obsessed with nudity. Carlos and Gabrielle must go to court to get custody of their baby. Bree's father Henry and stepmother Eleanor come to town to mediate between Andrew and her. Susan is convinced that Karl doesn't really love Edie. Later, she goes to a movie theater, and spots Mike with a date.

Sullivan and Natasha's past is revealed. Ben and Bailey have a discussion with Pru's grandparents. The crew responds to a fire at a candy factory.

When a pharmaceutical rep is murdered, Megan and the team must find the original crime scene if they hope to find out the cause of death and why the body was drained of blood. A big hurdle to overcome is the number of suspects with access to lots of unknown drugs.

When a popular 17-year-old high school student is found dead after a rave, the team must decipher various unknown drugs in his system and multiple bruises to figure out the cause of death.

When a female astronaut is found dead, Rosie and Villa launch into an investigation of America’s space program. Rosie navigates new dynamics regarding his latest health issue, and Villa’s long-lost brother returns to Miami.

The ghost of a man who was buried in the wrong grave starts to haunt a cemetery as someone else’s wife is coming to mourn him every night. Melinda must reconcile the man with his hostile wife and daughter in order for him to be able to cross-over.

When a pharmaceutical rep is murdered, Megan and the team must find the original crime scene if they hope to find out the cause of death and why the body was drained of blood. A big hurdle to overcome is the number of suspects with access to lots of unknown drugs.

When a female astronaut is found dead, Rosie and Villa launch into an investigation of America’s space program. Rosie navigates new dynamics regarding his latest health issue, and Villa’s long-lost brother returns to Miami.

Sullivan and Natasha's past is revealed. Ben and Bailey have a discussion with Pru's grandparents. The crew responds to a fire at a candy factory.

Carlos and Gaby learn the truth about their baby. An ex-stripper gives birth to her child, and Gabrielle holds her for the first time. Also, Paul Young comes to face his demons head on with Wisteria Lane. Lastly, Lynette is forced to give a court deposition about Bree's drinking and alcoholism.

The Station 19 crew offers aid to a man who sets himself on fire. Theo proves his devotion to Vic; Sullivan seeks advice from Dr. Webber; and Travis comes to a realization about his love life.

The Dean Miller Memorial Clinic has its opening day. Meanwhile, Sullivan gives Beckett an ultimatum, and the crew responds to a skydiving incident.

Sullivan and Natasha's past is revealed. Ben and Bailey have a discussion with Pru's grandparents. The crew responds to a fire at a candy factory.

Carlos and Gaby learn the truth about their baby. An ex-stripper gives birth to her child, and Gabrielle holds her for the first time. Also, Paul Young comes to face his demons head on with Wisteria Lane. Lastly, Lynette is forced to give a court deposition about Bree's drinking and alcoholism.